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colesevelam

Pronunciation: KOE le SEV e lam

Brand: Welchol

Welchol

slide 1 of 1, Welchol,

625 mg, oval, white, imprinted with Sankyo C01

Image of Welchol
slide 1 of 1
    

What is the most important information I should know about colesevelam?

You should not take this medicine if you have diabetic ketoacidosis, very high triglycerides, a history of bowel obstruction, or a history of pancreatitis caused by high triglycerides.

What is colesevelam?

Colesevelam is used to treat high cholesterol in adults and children at least 10 years old.

Colesevelam lowers "bad" cholesterol in the blood, which is also called LDL (low-density lipoprotein) cholesterol. Lowering your LDL cholesterol may reduce your risk of hardened arteries, which can lead to heart attacks, stroke, and circulation problems.

Colesevelam is sometimes used together with "statin" cholesterol medications such as atorvastatin, lovastatin, simvastatin, Crestor, Lipitor, Pravachol, Zocor, and others.

Colesevelam is also used to improve blood sugar control in adults with type 2 diabetes. This medication is not for treating type 1 diabetes.

Colesevelam may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking colesevelam?

You should not take colesevelam if you are allergic to it, or if you have:

  • very high levels of triglycerides (a type of fat) in your blood;
  • diabetic ketoacidosis (call your doctor for treatment);
  • a history of bowel obstruction; or
  • a history of pancreatitis caused by high triglycerides.

Colesevelam may increase your triglycerides (a type of fat in your blood), which can increase your risk of and that the long-term effect of hypertriglyceridemia on the risk of coronary artery disease is uncertain

Colesevelam is not for use in girls who have not yet started having menstrual periods.

Colesevelam should not be given to a child younger than 10 years old.

Tell your doctor if you have ever had:

  • trouble swallowing;
  • a stomach, intestinal, or digestive disorder;
  • surgery on your stomach or intestines; or
  • a vitamin A, D, E, or K deficiency.

Tell your doctor if you are pregnant or if you become pregnant.

The powder form of colesevelam may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).

How should I take colesevelam?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take colesevelam with a meal and a full glass of water or other liquid.

You may have to take several tablets at a time each time you take colesevelam. Tell your doctor if you have trouble swallowing the tablet whole.

Colesevelam powder must be mixed with 8 ounces of water, fruit juice, or a diet soft drink. Stir and drink this mixture right away. Add a little more water to the glass, swirl gently and drink right away.

You may need to follow a special diet to prevent constipation while using colesevelam. Follow all instructions of your doctor or dietitian.

Do not change the dose or timing of any other cholesterol or diabetes medications without your doctor's advice.

Colesevelam may increase your triglycerides (a type of fat in your blood), which can lead to pancreatitis (inflammation of the pancreas). You will need frequent blood tests.

Colesevelam is only part of a complete treatment program that may also include diet, exercise, and weight control. Follow your doctor's instructions very closely.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine (with food and a full glass of water) as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking colesevelam?

Avoid eating foods high in fat or cholesterol, or colesevelam will not be as effective.

What are the possible side effects of colesevelam?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using colesevelam and call your doctor at once if you have:

  • severe constipation;
  • severe stomach pain; or
  • pancreatitis --severe pain in your upper stomach spreading to your back, nausea and vomiting.

Common side effects may include:

  • constipation;
  • nausea; or
  • upset stomach.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect colesevelam?

Colesevelam can make some medicines much less effective when taken at the same time. If you take any of the following medicines, take them 4 hours before you take colesevelam:

  • cyclosporine;
  • olmesartan;
  • phenytoin;
  • levothyroxine or other thyroid medication;
  • birth control pills;
  • multivitamins;
  • warfarin (Coumadin, Jantoven); or
  • oral diabetes medication --chlorpropamide, glimepiride, glipizide, or glyburide, tolazamide, tolbutamide.

This list is not complete and many other drugs may affect colesevelam. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about colesevelam.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2019 Cerner Multum, Inc. Version: 11.01. Revision date: 6/25/2019.

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